EFFECT OF GLUCOPHAGE (METFORMIN HYDROCHLORIDE) TREATMENT IN IMPROVING FERTILITY OF POL YCYSTIC WOMEN

Abstract

In th is study patr nlS treated for three or si.x 111O I11h5 wilh ili co pl n~ (nlClformin) m'd cOI'l.:civcd idler glucophagc abne or \\ jlh combinlllioll treatment of glucophage nnd ovulution ilxillC lio n medicine were of )t>ungt'r ugc than those who d id nol t:on;c ivc. Younger plllic nls uncr six rno nths Ircnlrncnt wit h glucophaga.:. I'OllCe ;\cJ witho ul eve n IHk ingovukltio n indllClDfl medicines. rhe lreq ue ncy ofconccplioll'> in both primary lind sccolKlnry illrcrtilc palients in this stud y wus more ullcr six IllO lIlhs glucophagc IrCnl1llCn i. Secondary infertile patients respo nded the best 10 glucop1u1 b'C treatment nnd to lesser tl ose o f o vlI lation induction. The mean I3MI, WUi5110 hip ratio :lI1d libsc UPIl~ is skin told thickness indicated iJlsulin resistance. Allcr three Illo nt hs treatment with glueophage ill conceived patients there was highly signiriclt nl decl'C,lsc (P<O.OOI) in meal1 Fasting Blood Glucose and Fast ing Insulin. The pa tie nts who were given treatment for six mo nths had highly significa nt dce rcasc(P<O.OO I) ill Ill:an Fasting 13 bod Glucose li nd Fasting Insulin in conce ived and not conce ived patie nts, h owc \'er highly significa nt rise (P<O.OOI) in QUICKI aoo significn nt rise (P<O.05) in Glucose Insulin mtio was seen in conce ived pat ients. When comparison wns mnde Filsting bbod glucose Icvck dccre,lscd highly signifICantly (P<O.OO I) in pnli:nts who took glucophage fo r six mon th compared to p:lI ienls who took glucop hagc fOr three mo nths. These resu lts !>hcmcd lilill three UI six Ilio nth trettt n-.:: ul wd.1t ghcophitge tl:sultcd ill impro\cmcnt in insulin resistllnce in thcsc patie nts. The res ults showed tl l:11 in Po lycystc patie nts the high Senun Leplin Le ve ls elK! not shcl\v any significant decrease whe n glucoph.'lgc WllS give n rot' three mo nths bUI the significant decrease was sec n only when glucoplulgc dru g was given ro r si;.:. months ill conceivcd group o r pa lkmts. Serum LH :tIKI testosteronc leve ls dec reased highly signific:ltllly(P<O.OOI) where 'IS significant incfcilse (P<O.05) ill Serum ESlmcl c l leve ls WII'> observed in patients who were give n six Iln nlhs glucopl1a b'C treatme nt comlmred to pat e nts who were give n three lIn nths glucophagc treatme nt. The systolic :md ic bbod pressure decreased highly significa ntly (P<O.OOI) both in cOIl:civcd and no t conce ived patients of three mo nths and si.'( 11I0 ntl\5 glucophage trent men!. Serum cho lcstero llc,fc k dec reased significantly (P<O.O I) in conceived patie nts of three nn nlhs glucophilge trcatmem. however highly significanl dec rease (P<O.OOI) was seen in conce ived patie nts o f six months glucophagc trea tment. In th is study the ovcmll conccptD!l nllcr th ree months reatn nt with glucophagc wns highly significantly b w (p=0.0041) C01l11)urcd to those who were give n glucopllil ge ror six months. Ck:uniphc nc Citrule and Human MCllopnusal Gonadotrophins in combil1.:ltioll with V" gillcophage has pro ved to be a better med ic ine ro r the treatme nt Dr inrCI1ility in peos. This a Iso depe nd s on the age o rille pat ient as younge r patients respo nded to initia I (lesser dose) med ica tio n while o lder patic nts rcquilocd higher dose o r hlmlme nl. The ovcmll conception nller six mo nths trcn tlllClH with g illcoptlllge was significantly high than who were given g tucophage for three mo nth$. Live birth rate and single bit1hs weloc significllnlly higher in patients who contillllcd glucophagc during pregnancy duration. Abortio lls, still births and threa te ned abortio ns we re highe r in ratie nls who did 110 t cont inue g ucophage during the pregnancy.