Synthesis and Characterization of Some Bioactive β-Amino Alcohol Derivatives

Abstract

A series of new Schiff base derivatives of β-amino alcohols have been synthesized in good yields. The core structure of this series is 1-(2-hydroxy-3-(naphthalene-2- yloxy) propyl) isatin, which has been synthesized via ring opening reaction of naphthyloxy methyl oxirane intermediate with isatin (as nucleophile). The naphthyloxy methyl oxirane intermediate in turn was obtained by nucleophilic substitution reaction of naphthol with epichlorohydrin in presence of strong base. All the synthesized compounds were characterized by their physical and spectral (NMR) data and are expected to have good medicinal properties.