Synthesis and Characterization of Alginate Nanoparticles as a Drug Delivery Vehicle

Abstract

Nanoparticles are widely used in different areas where polymeric nanoparticles are used for the drug delivery. The current study deals with the synthesis of alginate nanoparticles loaded with Bisoprolol fumarate, a beta 1 selective blocker drug. These nanoparticles were formed by ionotropic pre-gelation method with calcium as a cross-linker. Different strategies were employed to form the Bisoprolol loaded alginate nanoparticles. The concentration of sodium alginate was kept fixed at 1% but the crosslinker calcium ion concentration was altered. Four different strategies were followed for synthesis and formation of alginate nanoparticles. The particles formed were dissolved in distilled water, centrifuged immediately after formation, kept for 24 hours before centrifugation and calcium dissolved in 40% ethanol solution. The comparison of the FTIR spectra of blank alginate nanoparticles and Bisoprolol loaded nanoparticles. The spectrum confirmed the stretches of the alginate remained approximately the same with minor variations. The vibrations around 2000 cm-1 were because of the stretches of alkynes and alkenes because of the bisoprolol present in the alginate nanoparticles. The carboxyl group stretch of symmetrical and asymmetrical become less broad or narrowed when bisoprolol was added. The results of the absorption bands of bisoprolol loaded alginate nanoparticles revealed that the bisoprolol was encapsulated in the polymeric structure of alginate. SEM images revealed that the nanoparticles formed are well dispersed and discrete having size range of 120-300nm. After the disclosed results it is concluded that the alginate nanoparticles formed can be used as a carrier of Bisoprolol for cardiac protection