Synthesis of aryl/heterocyclic sulfonyl cycle ureas as antidiabetic agents

Abstract

After the biguanides only one class of oral hypoglycemic agents is seen in the market, "the sulfonyl ureas". Tolbutamide, glibenclamide and tolazamide are the important sulfonyl urea drugs used for the treatment of non insulin dependent diabetes mellitus. Different pharmaceutical companies are marketing a number of antidiabetic drugs having these sulfonyl ureas as active ingredients under different trade names. During the last two decades, literature is over-loaded with the synthesis and antidiabetic activity of many acyclic aryl/heterocyclic sulfonyl ureas. In recent literature some new aryl sulfonyl urea derivatives with appreciable hypoglycemic activity have been reported!. Among heterocyclic acyclic sulfonyl urea derivatives 3-methyl-5-phenylpyrazole- sulfonyl urea derivatives have been reported as hypglycemic agents2 . The potency of these is more than that of phenformin. 3,4,5-Trisubstituted pyrazole sulfonyl urea derivatives3 have also been repOlied as hypoglycemic agents and among them compound having carboxylic acid group at position-4 is much more active than the corresponding trisubstituted pyrazoles. It has also been repOlied that pyrazole sulfonyl urea derivatives are much more active than the corresponding thiourea analogues4 . Amino acid derivatives of sulfonyl urea have also been repOlied as antidibetic agents5