Investigation of anti rheumatoid drugs with in micelles of different surfactants

Abstract

Surfactants have amphiphatic structure. The structure of surfactant causes not nly concentration of surfactant at surface and reduction of surface tension of solvent but also orientation of molecules at surface. Surfactant molecules self associate to form cluster, known as micelles and phenomenon is micellization. Solubilization of drugs by aqueous micellar solution of sodium dodecyl sulphate (SDS) and cetyltrimethyl ammonium bromide (CTAB) have been studied as the function of surfactant concentration by different methods. The depression in critical micelles concentration (CMC) of surfactants with different concentration of drugs were determined by conductivity method at 2SoC. Anti-rheumatoid drugs are pain-killer. Some of which were used as additive such as flurbiprofen, ibuprofen and aspirin. These drugs have prominent anti-inflammatory, analgesic and antipyretic action. The flurbiprofen and ibuprofen mechanism of action is by inhibitor of enzyme cyclo-oxygenase resulting in reduced prostaglandin synthesis. Flurbiprofen also potent inhibitor of platelet aggregation due to inhibition of thromboxane formation. Aspirin inhibits fatty acid cyclogenase by acetylation of active site of enzyme. Interaction of drugs with micelles "which act as drugs carriers" of anionic and cationic surf act ants were discussed by conductometric and spectroscopic methods using physical parameter like partition coefficient "Kx" and free energy change "L10p". It is concluded that flurbiprofen is more incorporated/penetrated into micelles as compared to ibuprofen and aspirin.