SYNTHESIS CHARACTERIZATION AND BIOLOGICAL ACTIVITY OF SOME METAL COMPLEXES OF QUINOLONE FAMILY OF ANTIBIOTICS

Abstract

Metal complexe& of two very important antibiotics of flouroquinolone family i.e. Ciprofloxacin and Norfloxacin were made. All the metals from first transition series were used for complexation except Titanium, from second transition series Zirconium was used. All metal complexes were made in 2: 1 ligands to metal ratio. Mixed ligand metal complexes using 2, 2' Bipyridyl along with the drugs were also prepared using the same ratio of ligand to metal. Complexes were characterized using FT-IR spectroscopy and metal analysis. FT-IR analysis shows that the carboxylic acid peak which was appeared at 1708 cm-1 and 1731cm-1 respectively in spectrum of Ciprofloxacin and Norfloxacin were shifted towards lower wave number in spectrum of complexes i.e. bonding was done through carboxylic acid group. It also confirmed the purposed structure of complexes. Metal analyses by atomic absorption spectroscopy were also confirmed that the metal contents were found similar to that calculated theoretically. To check the effectiveness, the metal complexes are tested against four strains of microorganisms i.e. Salmonella typhae, Bascillus subtilus , Staphlus coccus aurius , E. coli . . ill comparison with plane drugs (ligands) using "well diffusion" method All the complexes have shown comparable activity against these organisms, and few have shown greater activity than plane drugs