Design, Synthesis of Phenoxymethylcoumarin Clubbed 4- Arylthiazolylhydrazines and Methylsulfonamidophenyl Linked Aryl-Oxadiazolylthioacetamides for Prospective Biological

Abstract

Hybrid pharmacophoric approach (HPA) has gained great consideration in recent years as it leads to the production of a novel hybrid molecule with a better target ability. Due to the immense significance of heterocycles in medicinal chemistry, the heterocyclic moieties have been hybridized together with a known drug to synthesize an efficient molecule. Moreover, synthetic methodologies could be employed to introduce the structural diversity in known drugs. The present work has utilized the hybrid pharmacophoric approach and leads to the synthesis of novel molecules which may have enhanced pharmacological properties of both structural sub-units. In the first part, Nimesulide, a known antipyretic drug has been linked with oxadiazole thiols through an acetamide linkage to synthesize (7a-g) molecules. While the second part of the dissertation outlined the synthesis of coumarin-azomethine-thiazole conjugates (14a-k). These conjugates were synthesized through a well-known method; Hantzsch-thiazole synthesis. All the synthesized compounds were isolated in moderate to excellent yield. The anticipated structures of synthesized molecules (7a-g) and (14a-k) were then determined via 1H-NMR, 13C-NMR, and FT-IR spectroscopic techniques. Further, the obtained physical data also supported the predicted structure of synthesized molecules.