Amino acids based Sulphonamides and their hybridization with Substituted Piperazine and Metronidazole drug; Synthesis, Characterization and their Antibacterial potential

Abstract

Sulfonamide and carboxamide functionalities play a vital role in pharmaceutical industry, polymer chemistry and agrochemicals. Keeping in view the importance of these functionalities, several modem and efficient methodologies have been developed for their synthesis. Moreover nitro imidazole-based compounds exhibit plethora of biological importance. The aim of this research work is the synthesis of a number of amino acids-based sulfonamides and their hybridization with metronidazole and substituted piperazine through ester and amide linkages, in view of finding more potent compounds. Sulfonamides were synthesized in the aqueous medium from sulphonyl chlorides and amino acids, while esters and carboxamides were synthesized using acyl transfer reagents EDC and DMAP. These compounds were obtained in moderate yield and characterized by lH NMR, l3C NMR and other physical parameters. The synthesized compounds containing different R-groups are the result of tweaking chemical structures of existing and reported potential drug through hybridization, which may seem to have antibacterial properties.