Study of consanguinity and premature rupture of membranes in gestating women and their association with neonatal outcome.

Abstract

Premature rupture of membrane (PROM) is a complicating factor in as many as one-third of premature births. During preterm premature rupture of membranes, both the mother and the fetus are at greater risk of complications. This study was a cross sectional study and it was conducted to examine the socio-demographic factors affecting maternal and neonatal health with respect to premature rupture of membranes. The main focus of the study was to find out the association of consanguinity with premature rupture of membranes. The data were collected from Pakistan Institute of Medical Sciences Islamabad. Though the major proportion of the subjects was from urban areas but one cannot overlook its occurrence in rural and underdeveloped areas due to lack of awareness and the women are underprivileged to get maximum health care facilities. The results showed a significant association of premature rupture of membranes with consanguinity, pregnancy related parameters, language and family types of the subjects whereas no association was found with the origin, caste, literacy, occupation, province and age group of the subjects. The association of the neonatal outcome with this pregnancy related condition was also evaluated and analyzed; it was observed to be significantly associated with the distribution of neonates but no significant association was obtained with the gender, birth weight, single or mUltiple gestation and congenital anomalies in neonates of subjects exposed to premature rupture of membranes. Further studies are required to fully understand the combined effect of premature rupture of membranes and other maternal factor on pregnancy outcome