The Effect of Selective COX-2 Inhibitor and Methylcobalamin on Regeneration of Rabbit Sciatic Nerve

Abstract

Fig- 1: Prostaglandin synthesis pathway after inj ury or trauma. After an injury or trauma, arachidonic acid is formed by phospholipase acti vity. Arachidonic acid is converted to PGH2 via PGG2, whi ch is the common precursor for the synthesis of PGs. COX inhibitors block the activity of the enzyme cyclooxygenase, thus inhibiting the fo rmation of PGG2 (Vane, 197 1) ................................... .... ................ .... .. . 34 Fig- 2: Regression analysis of variance showed that there was no increase in mean density of normal myelinated nerve fibers in different durations of experiments in Control group. Increase in mean density of normal myelinated nerve fi bers on duration of experiment in Crushed Control group was not significa nt, the same was also observed in the case of Celecoxib treated group . The highl y significant increase in mean density of normal myelinated nerve fi bers was observed in the case of Methylcobalamin treated group with the increase in duration of treatment.. .. ...... .... ........ 47 Fig- 3: Regression analysis of variance showed there was no change in mean diameter of normal myelinated nerve fibers in different durati ons of experiments in Control group. The non-significant decrease in mean diameter of normal mye linated nerve fibers was observed on duration of experiment in Crushed Control group. The significant decrease in mean diameter of normal myelinated nerve fi bel's was observed in the Celecoxib and Methylcobalamin treated groups with the increase in duration of treatn1ent.