Synthesis, Characterization and DNA Binding Studies of Cadmium (II) Carboxylates with Nitrogen Donor Heteroligands

Abstract

New series of novel homoleptic and heteroleptic Cd (II) carboxylates were synthesized and characterized by using FT-IR, multinuclear NMR ('H and 13C-NMR) spectroscopy and single crystal X-ray diffraction. The ligands used were cyclopropane carboxylic acid and cyclopentane carboxylic acid. For the heteroleptic complexes N -donor ligands (1,10- phenanthroline, 2,2'-bipyridine and 2,9-dimethyl-l,10-phenanthroline) were added along with the sodium salt of ligand. Spectroscopic data of the synthesized complexes manifest the disappearance of -OH band in the spectra of complexes in comparison with the spectra of the free ligands, which confirmed the complex formation. The nature of complex-DNA interaction and the effect of attachment of heteroligand on binding strength of the complexes were studied through UV-Visible spectroscopy and cyclic voltammetry. The results showed mixed mode of binding i.e, intercalation and groove binding. The DNA binding constants (Kb) and Gibb's free energy changes (~G) were calculated for these complexes. Purpose of this study was to design effective drugs with less harmful effects which could be beneficial for mankind.