Synthesis, Characterization and Biological Activities of Mixed Ligands Copper(II) 4-(4-nitrophenyl)piperazine1-carbodithioates

Abstract

Three new copper(II) compounds, [Cu(2,2-bipyridyl)ClL] (1), [Cu(1,10-phenanthroline)ClL] (2) and [Cu(ethylenediamine)ClL] (3), where L = 4-(4-nitrophenyl)piperazine1-carbodithioates, have been synthesized and were characterized by elemental analysis, FT-IR, UV-Visible spectroscopy and cyclic voltammetry. Spectroscopic analysis confirmed the monodentate behavior of ligand (L) and a square-planar geometry around Cu atom. The cyclic voltammetric results (CV) revealed that the redox behavior of the complex 1, is highly pH dependent. A subsequent DNA interaction of complexes 1and 2 by CV proved them to be good DNA binders. In addition to this, complexes 1 and 2 have shown the scavenging activity against DPPH free radicals, and the former complex is a head in this race than latter as evident from their ICR50R values.