Estimation of serum uric acid concentration in coronary heart disease patients

Abstract

Sc.:mm uric aCId (SUA) levt:l was estimated in tifty h\!81lhy and fifty diseuse p3liellts to find out its correlat ion with coronary heart disea:,e (CliO) events. Among CHO groups these patients were diagnosed by 111yocardial infarction, ung,iography, thalliUIll scan, exercise stress test (ETT) either singu larly or in various combinations. A positive correlation has been found between elevated SUA level and CI-ID. The study has revealed that pat ients with CHD has raised SUA \vhich was stati stica lly significant (0.036). Mean values of SUA concentration for healthy and coronary hea rt disease palients were found to be 298.28 ± 94.58 and 333.88 ± I 05.80, ~ mollL respectively. A correlation of serum uric acid was also found with age, body mass index (BMI) and diel of CHD patients. With differenl age groups viz. 35-39,40-44,45-49 and 50-54 years, SUA level was found 10 be 303. 12 ± 114.53,349.00 ± 113 .28.337.35 ± 92.03 and 378.00 ± 115.61 ~tnolfl- in CHD patients which is higher respeclively than SUi\. level of healthy individuals in these groups. With different ranges of BMI viz .. 18- 20,2 1-23, 24-26 and 27-29 of heallhy and CHD paliellts, SUA level increased wilh an increase in BMI in both the groups. Persons with CHD (28% fatty) showed an increase in serum uric acid level than nomlal healthy subjects. Higher serum mic acid has been found in fatty (overweight) and old age peoples. Such information determine certain metabolites can he proven valuable in finding out the actual causes of CHD.